Precision Environmental Health, Aging, Epigenetic Epidemiology

1. National Natural Science Foundation of China (82304098). Impact of black carbon exposure on the cognitive function of older adults: a mechanistic investigation of the DNA methylation dynamic regulation of SLC25A51. 2024.01 – 2026.12. PI

2. Open Foundation of China CDC Key Laboratory of Environment and Population Health (2022-CKL-03). Effects of chronic exposure to cadmium and arsenic on frailty and DNA methylation mechanisms in the older adults. 2022.01-2023.12. PI

3. China National Key R&D Program (No. 2022YFC3702704). Investigation on the life course health effect spectrum of air pollution exposure in Chinese residents. 2022.10-2026.03. Key investigator

4. NIH R01 (R01ES025225): Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging Cohort. 2018 – 2020 Co-investigator

5. NIH R01 (R01ES027747): Air Particulate, Metals, and Cognitive Performance in an Aging Cohort – Roles of Circulating Extracellular Vesicles and Non-coding RNAs. 2018 – 2020 Co-investigator

6. Fondazione Cariplo (Bando Ricerca Malattie invecchiamento, #2017-0653): The Trithorax and Polycomb group proteins UTX and EzH2 in the Frailty Syndrome. 2017-2020 Co-investigator

1. Gao X*, Tong G, Jiang M, Huang N, Zheng Y, Belsky D*, Huang T. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants. Nature Communications, 2023, doi: 10.1038/s41467-023-38013-7. (IF = 16.6)

2. Gao X*, Jiang M, Huang N, Guo X, Huang T. Long-Term Air Pollution, Genetic Susceptibility, and the Risk of Depression and Anxiety: A Prospective Study in the UK Biobank Cohort. Environmental Health Perspectives, 2023, doi: 10.1289/EHP10391. (IF = 10.4)

3. Gao X#, Huang J#, Cardenas A, Zhao Y, Sun Y, Wang J, Xue L, Baccarelli AA, Guo X, Zhang L, Wu S. Short-Term Exposure of PM2.5 and Epigenetic Aging: A Quasi-Experimental Study. Environmental Science & Technology, 2022, doi: 10.1021/acs.est.2c05534. (IF = 11.4)

4. Gao X*, Koutrakis P, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AA. Short-term exposure to PM2.5 components and renal health: findings from the Veterans Affairs Normative Aging Study. Journal of Hazardous Materials. 2021; 420:126557. doi: 10.1016/j.jhazmat.2021.126557. (IF = 13.6)

5. Gao X*, Coull B, Lin X, Vokonas P, Spiro A III, Hou L, Schwartz J, Baccarelli AA. Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study. Nature Aging. 2021; 1(5):430-437. doi:10.1038/s43587-021-00060-4. （IF = 16.6; Nature Aging当期封面文章）

6. Gao X*, Coull B, Lin X, Vokonas P, Sparrow D, Hou L, DeMeo D, Litonjua A, Schwartz J, Baccarelli AA. Association of Neutrophil to Lymphocyte Ratio with Reduced Pulmonary Function in a 30-Year Longitudinal Study of US Veterans. JAMA Network Open. 2020; 3:e2010350. (IF = 13.8)

7. Gao X*, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AA. Nonsteroidal anti-inflammatory drugs modify the effect of short-term air pollution on lung function. American Journal of Respiratory and Critical Care Medicine. 2020; 201(3):374-8. (IF = 24.7)

8. Gao X*, Colicino E, Shen J, Kioumourtzoglou MA, Just AC, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA. Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective. Environment International. 2019; 126, 395-405. doi: 10.1016/j.envint.2019.02.053. (IF = 11.8)

9. Gao X, Gào X, Zhang Y, Holleczek B, Schöttker B, Brenner H. Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people. European Journal of Epidemiology. 2019; 451-462. (IF = 13.6)

10. Gao X*, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA. Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males. International Journal of Epidemiology. 2019; 48, 1958-1971. (IF = 7.7)