细胞与分子毒理学、化学致癌作用、毒物基因组学、靶器官毒理学。

1. 国家重点研发计划课题，2017YFC1600203，基于毒作用机制和健康效应终点的食品稀土元素和添加剂的安全性评估，2018.01~2021.12，项目骨干。

2. 国家自然科学基金面上项目（青年-面上连续资助项目），81370079，基于细胞应激反应途径组合测试和毒物基因组学预测化学物肝、肾靶器官毒性，2014.01~2017.12，项目负责人。

3. 北京市自然科学基金面上项目，7132122，基于BaP恶性转化16HBE细胞成瘤裸鼠血清蛋白质组学筛选肿瘤生物标志，2013.01~2015.12，项目负责人。

4. 国家自然科学基金青年科学基金项目，81001253，毒物细胞应激反应途径识别和肝、肾靶器官毒性预测，2011.01~2013.12，项目负责人。

5. 新型溶瘤病毒（BioTTT001）单次腹腔内注射给予荷瘤金黄地鼠的组织分布研究，2020.7~2021.1，项目负责人。

6. 可表达PD-1多肽的新型溶瘤腺病毒临床前体内药效学研究，2021.9~2022.3，项目负责人。

1. Zhou C, Ma X, Chen J, Li L, Wang Y, Xing Y, Fu J, Yao B, Chang B*, Zhao P*. Untargeted metabolomics and lipidomics analysis identified the role of FOXA1 in remodeling the metabolic pattern of BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2021; 426: 115640.

2. Wang Y‖, Li L‖, Hao M, Fu D, Chen J, Zhou C, Fu J, Yao B, Chang B*, Zhao P*. Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2020; 403: 115160.

3. Li L, Chen J, Wang Y, Zhou C, Ma X, Fu J, Yao B, Zhao P*. MicroRNA expression profiling and the role of ALCAM modulating tumor growth and metastasis in benzo[a]pyrene-transformed 16HBE cells. Toxicology. 2020; 442: 152539.

4. Wang Y‖, Jia Y‖, Yan L, Fu J, Hao M, Chen W, Yao B, Zhao P*, Zhou Z*. Clusterin and neuropilin-2 as potential biomarkers of tumor progression in benzo[a]pyrene-transformed 16HBE cells xenografted nude mouse model. Chem Biol Interact. 2017; 275: 145-151.

5. Zhao P*, Fu J, Yao B, Jia Y, Zhang H, Li X, Dong L, Gao Y, Liu W, Chen W, Zhou Z*. Label-free quantitative proteomic analysis of benzo(a)pyrene-transformed 16HBE cells serum-free culture supernatant and xenografted nude mice sera. Chem Biol Interact. 2016; 245: 39-49.

6. Zhao P, Fu J, Yao B, Song Y, Yuan L, Jia Y, Ma S, Chen W, Zhou Z*. The cell cycle distribution should be given more consideration in cell-based in vitro toxicological studies. Arch Toxicol. 2014; 88: 337-343.

7. Zhao P, Fu J, Yao B, Hu E, Song Y, Mi L, Li Z, Zhang H, Jia Y, Ma S, Chen W, Zhou Z*. Diethyl sulfate-induced cell cycle arrest and apoptosis in human bronchial epithelial 16HBE cells. Chem Biol Interact. 2013; 205: 81-89.

8. Zhao P, Fu J, Yao B, Song Y, Mi L, Li Z, Shang L, Hao W*, Zhou Z*. In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene. Toxicol In Vitro. 2012; 26: 362-368.

9. Zhao P‖, Zhang L‖, Zhong W, Ying X, Huang H, Yao B, Yuan Z, Fu J, Wang Y, Zhou Z*. Antigen-subtracted 2-DE/MS strategy, a novel proteomic analysis platform. Arch Toxicol. 2011; 85: 35-41.

10. Zhao P, Zhong W, Ying X, Yuan Z, Fu J, Zhou Z*. Manganese chloride-induced G0/G1 and S phase arrest in A549 cells. Toxicology. 2008; 250:39-46.