老年营养、营养与疾病、精准营养

1、国家自然科学基金面上项目（基于肠道菌群为靶点探讨燕麦葡聚糖延缓糖尿病肾病进展的机理研究）

2、国家自然科学基金青年项目（原花青素减少2型糖尿病肾病发生及抗炎机制研究）

3、教育部博士点基金（低聚原花青素改善高糖状态下足细胞裂孔隔膜结构和功能的分子机制）

4、达能营养中心膳食营养研究与宣教基金（植物甾醇对我国高胆固醇血症患者的干预研究）

5、横向课题：叶黄素和玉米黄质对蓝光损伤视网膜黄斑变性的作用及机制研究

6、横向课题：燕麦麸调控糖脂代谢的作用及机制研究

7、横向课题：发酵黄芪降尿酸的作用及机制研究

8、横向课题：羊乳清蛋白和羊乳酪蛋白对少肌症的影响及作用机制研究

9、横向课题：羊乳全脂粉和羊乳低脂粉对少肌症的影响及作用机制研究

1) Zhaofeng Zhang, Yujie Li, Yong Li. Grape seed proanthocyanidin extracts prevent hyperglycemia-induced monocyte adhesion to aortic endothelial cells and ameliorates vascular inflammation in high-carbohydrate/high-fat diet and streptozotocin-induced diabetic rats. Int J Food Sci Nutr. 2015 Aug;67(5):524-34.

2) Li Zhang, Jiao Yang, Zhangyi Liao, Xiaomeng Zhao, Xuefeng Hu, Wenli Zhu, Zhaofeng Zhang*.  Association between Diabetes and Cognitive Function among People over 45 Years Old in China: A Cross-Sectional Study. Int J Environ Res Public Health. 2019 Apr 11;16(7)

3) Xiaxia Cai, Lei Bao, Jinwei Ren, Yong Li, Zhaofeng Zhang*. Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro. Food Funct. 2016 Feb;7(2):805-15

4) Lei Bao, Xiaxia Cai, Zhaofeng Zhang*, Yong Li*. Grape seed procyanidin B2 ameliorates mitochondrial dysfunction and inhibits apoptosis via the AMP-activated protein kinase-silent mating type information regulation 2 homologue 1-PPARγ co-activator-1α axis in rat mesangial cells under high-dose glucosamine. Br J Nutr. 2015 Jan 14;113(1):35-44.

5) Lei Bao, Xiaxia Cai, Xiaoqian Dai, Ye Ding, Yanfei Jiang, Zhaofeng Zhang*, Yong Li. Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-γ coactivator 1α in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats. Food Funct. 2014 Aug;5(8):1872-80

6) Sumiya Aihemaitijiang, Yaqin Zhang, Li Zhang, Jiao Yang, Chen Ye, Mairepaiti Halimulati, Wei Zhang, Zhaofeng Zhang*. The Association between Purine-Rich Food Intake and Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents. Nutrients. 2020 Dec 15;12(12):3835.

7) Chen Ye, Xiaojie Huang, Ruoyu Wang, Mairepaiti Halimulati, Sumiya Aihemaitijiang, Zhaofeng Zhang*. Dietary Inflammatory Index and the Risk of Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents. Nutrients. 2021 Dec 16;13(12):4504.

8) Yaqin Zhang, Jiao Yang, Ninghua Huang, Linyan Xiao, Hong Lin, Jiayou Luo, Zhaofeng Zhang*, Zhiyong Zou*. Changes in breast milk lutein concentrations and their associations with dietary lutein intake: a 12-week prospective analytical study. Br J Nutr. 2019 Nov 14;122(9):1033-1039.

9) Chen Ye, Sumiya Aihemaitijiang, Ruoyu Wang, Mairepaiti Halimulati, Zhaofeng Zhang*. Associations between Early-Life Food Deprivation and Risk of Frailty of Middle-Age and Elderly People: Evidence from the China Health and Retirement Longitudinal Study. Nutrients. 2021 Aug 31;13(9):3066.

10) Jiao Yang, Dankang Li, Yaqin Zhang, Li Zhang, Zhangyi Liao, SuMiYa Aihemaitijiang,Yanmei Hou, Zhijun Zhan, Kui Xie, Zhaofeng Zhang*. Lutein Protects the Retina from Blue LED light-Induced Degeneration by Inhibiting Increasing Oxidative Stress and Inflammation. Journal of Functional Foods. 2020(73): 104107