慢性病分子流行病学、医学科研数据挖掘

1.肿瘤病人的免疫状态评估(北京市科委重大科技项目，2002-2006，子课题负责人)。

2.低出生体重的分子遗传流行病学研究(国家计生委重大攻关课题，2000-2004,课题负责人)。

3.抑郁症早期诊断方法和标准化综合治疗模式的研究（国家十一五项目，2008—2012，子课题负责人）。

4.重大慢性非传染性疾病风险评估与预测（国内合作项目，2012-2016，课题承担人）。

5.北京市房山区成人2型糖尿病发病风险模型的建立与评估（国家自然基金面上项目，2012-2015，课题承担人）。

6.重大慢性疾病风险预测、早期风险筛查、个性化健康管理和亚健康重点人群动态队列建设技术服务（国内合作项目，2014-2019，课题承担人）。

7.中国急性心肌梗死救治项目指标体系建立与评估（中国医师协会合作项目，2016-2018，子课题承担人）。

8.EPICOR Asia急性冠脉综合征中国延长随访研究（阿斯利康中国合作项目，2017-2019，子课题承担人）。

9.基于患病不一致同胞对代谢综合征的基因多效性研究（北京市自然基金面上项目，2018-2020，课题承担人）。

10.基于家系研究设计的2型糖尿病发病遗传培育效应研究（国家自然基金面上项目，2019-2022，课题承担人）。

1.Jun Zhang,  Feng Zhou, Xu Ran,  Ping Ye, Si Chen, Xiaotong Dai, Dafang Chen, Baoguo Jiang. Reliability and validity an indicator system used to evaluate outpatient and inpatient satisfaction in Chinese hospitals.Patient Preference and Adherence. 2018:12. 2527–2536.

2.Qiwen Zheng, Hui Liu, Jun Zhang, Dafang Chen. The Effect of Ambient Particle Matters on Hospital Admissions for Cardiac Arrhythmia: A multi-city case-crossover study in China. Environmental Health, 2018 Jul 16;17(1):60. doi: 10.1186/s12940-018-0404-z. 

3.Xiaotong Dai, Hui Liu, Dafang Chen, Jun Zhang. Association between ambient particulate matter concentrations and hospitalization for ischemic heart disease (I20-I25, ICD-10) in China: A multicity case-crossover study. Atmospheric Environment 186 (2018) 129–135. 

4.Si Chen, Ying Yang, Guan-Liang Cheng, Jia Jia, Fang-Fang Fan,Jian-Ping Li,Yong Huo, Yan Zhang, Da-Fang Chen. Association between short sleep duration and carotid atherosclerosis in Chinese Community Population. J Epidemiol Community Health.  2018 Jun;72(6):539-544. 

5.Keye Wu， Aiqun Huang， Si Chen， Wei Zhao， Huanqing Hu， Qi Yang; Dafang Chen. Arrendance at prenatal care and adverse birth outcomes in China: a follow-up study based on Maternal and Newborn’s Health Monitoring System. Midwifery,  57（2018）26-31.

6.Xiaozhu Wang, Yu Huang, Ming Yan, Jiuwei Li, Changhong Ding, Hong Jin, Fang Fang, Yanling Yang, Baiyan Wu, Dafang Chen. Molecular spectrum of excision repair cross-complementation group 8 gene defects in Chinese patients with Cockayne syndrome type A. Scientific Reports 7, Article number: 13686 (2017) doi:10.1038/s41598-017-14034-3.

7.Liu ZK, Wu KY, Dai XT, Che QZ, Chen S, Jia J2, Li JP, Huo Y, Zhang Y, Chen DF. The grading effect of abnormal glucose status on arterial stiffness and a new threshold of 2-hour post-load glucose based on a Chinese community study.J Diabetes Investig. 2017 Sep 1. doi: 10.1111/jdi.12741.

8.Duan F, Guo Y, Zhang L, Chen P, Wang X, Liu Z, Hu Y, Chen S, Chen D. Association of KCNQ1 polymorphisms with gliclazide efficacy in Chinese type 2 diabetic patients. Pharmacogenetics and Genomics. 26(4):178–183, APR 2016.

9.Liu-wei ZHANG, Jian-ping LI, Fang-fang DUAN, Zhi-ke Liu, Zi-qing Ma, Jin LI, Jie Jiang, Yan Zhang, Yong HUO, Da-fang CHEN. Synergistic effect of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population. BMC Cardiovascular Disorders. 2014,14:170.

10.Di-Qing Luo, Xiao-Zhu Wang, Yan Meng, Ding-Yang He, Ying-Ming Chen, Zhi-Yong Ke, Ming Yan,Yu Huang and Da-Fang Chen. Mandibuloacral dysplasia type A-associated progeria caused by homozygous LMNA mutation in a family from Southern China. BMC Pediatrics 2014, 14:256.